|
KMID : 1188320130070030317
|
|
Gut and Liver
2013 Volume.7 No. 3 p.317 ~ p.322
|
|
|
Helicobacter pylori Infection Enhances Gastric Mucosal Inflammation in Individuals Carrying the 260-T Allele of the CD14 Gene
|
|
Kim Eun-Jung
Chung Woo-Chul
Lee Kang-Moon
Paik Chang-Nyol
Kim Sang-Bae
Oh You-Suk
Lee Yang-Woon
Kang Sung-Goo
Noh Seung-June
|
|
|
Abstract
|
|
|
Background/Aims:We aim to evaluate the association between promoter polymorphism of the clusters of differentiation 14 (CD14) gene and Helicobacter pylori-induced gastric mucosal inflammation in a healthy Korean population.
Methods:The study population consisted of 267 healthy subjects who visited our hospital for free nationwide gastric cancer screening. Promoter polymorphism at -260 C/T of the CD14 gene was determined by polymerase chain reaction and restriction fragment length polymorphism analysis. The severity of gastric mucosal inflammation was estimated by a gastritis score based on the sum of the values of the grade and activity of the gastritis. Expression of soluble CD14 (sCD14) was assessed by quantitative sandwich ELISA.
Results:CD14 polymorphism was not associated with H. pylori infection. There were no significant differences in gastritis scores among the genotype subgroups, but subjects carrying the CD14 -260 CT/TT genotype had significantly higher sCD14 levels than those carrying the CC genotype. Subjects with the 260-T allele of the CD14 gene and H. pylori infection had significantly higher sCD14 levels than those with the same genotype but without infection.
Conclusions:In individuals with the T allele at the -260 site of the promoter region of the CD14 gene, H. pylori infection accentuates gastric mucosal inflammation.
|
|
|
KEYWORD
|
|
|
Helicobacter pylori, CD14, Genetic polymorphism, Gastritis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|